The highlight of Nauseda's visit to the US, which will end on Thursday, will be his address at the General Assembly session, scheduled for Wednesday.
Diplomats say the president will likely speak about the importance of international law, Russia's threat and sustainable development goals.
Nauseda is also scheduled to attend a climate change summit and to meet with potential investors.
The program of the visit also includes a bilateral meeting between Nauseda and British Prime Minister Boris Johnson to discuss Brexit, according to diplomatic sources.
The president is accompanied on his US trip by First Lady Diana Nausediene.